The gut wall provides an effective barrier against nanoparticle uptake

• Heike Sinnecker,
• Thorsten Krause,
• Sabine Koelling,
• Ingmar Lautenschläger and
• Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2092–2101, doi:10.3762/bjnano.5.218

• . Results: The particles were administered as bolus into the isolated intestine, and samples from the luminal, vascular and lymphatic compartments were collected over time. NP amounts in the different fluids were determined by fluorescence measurements. No particles could be detected in the vascular and

• provides an effective barrier against NP uptake whereby the mucus film seems to play an important role. Keywords: barrier; isolated intestine; mucus; nanoparticles; uptake; Introduction To the same extent that nanoparticles (NPs) find their way into foods, drugs, cosmetic articles and other consumer

• -functionalized polystyrene particles of three different sizes (20, 40 and 200 nm) (Table 1). For uptake studies, the particles were administered into the isolated intestine, samples from the luminal, vascular and lymphatic compartments were collected over the time course of the experiment and particle